Population
4 subjects with severe familial HDL deficiency in three French-Canadian kindreds with autosomal codominant…
Design
Case_series
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Does not alter clinical evaluation of hypoalphalipoproteinemia; leaves open novel genetic or efflux defects in familial cases.
Severe familial HDL deficiency in these French-Canadian kindreds is not caused by mutations in the apo AI-CIII-AIV gene cluster, LCAT, or lipoprotein lipase genes, suggesting an alternative mechanism such as altered HDL-mediated cholesterol efflux.
Marcil et al. (1995) studied this question.
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