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May 31, 2026Molecular Biology and EvolutionOpen Access

Intrahost mutational dynamics parallel long-term genome evolution in endosymbionts

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Authors

YKYounghwan KwakGBGordon Bennett

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Overview

Randomized trial investigates genetic variation in endosymbionts, suggesting insights into their evolution.

Key Points

  • This research aims to understand the microevolutionary processes of endosymbionts within their hosts and how intrahost dynamics influence long-term genome evolution.
  • Measured intrahost genetic diversity of Karelsulcia and Nasuia endosymbionts from Macrosteles quadrilineatus
  • Analyzed repeat-associated indels in Karelsulcia and single-nucleotide mutations in Nasuia
  • Evaluated mitochondrial heteroplasmy in relation to endosymbiont nucleotide diversity
  • Karelsulcia showed sparse variation dominated by repeat-associated indels
  • Nasuia exhibited significant single-nucleotide mutations affecting essential genes
  • Intrahost mutational patterns align with long-term evolutionary changes observed over ∼11 years

Cite This Study

Kwak et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2675783ba022b6fdd4bhttps://doi.org/10.1093/molbev/msag131
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