Why the study?
Post-exercise elevations of cTnT and cTnI are often interpreted interchangeably despite suggestions that post-exercise kinetics might differ between isoforms.
Do the kinetics of cTnT and cTnI differ after 60 min continuous swimming in young participants?
Do the kinetics of cTnT and cTnI differ after 60 min continuous swimming in young participants?
Post-exercise kinetics of cTnT and cTnI differ significantly, with cTnT peaking earlier than cTnI, suggesting they should not be interpreted interchangeably in the context of exercise.
Post-exercise elevations of cardiac troponin T (cTnT) and I (cTnI) are often used in isolation but interpreted interchangeably. Research suggests, however, that post-exercise cTn kinetic might differ with each isoform. In this cross-sectional observational study, we collected blood samples before, immediately after (5 minutes), and at 1-, 3-, 6-, 12-, and 24-hour post-exercise in a mixed cohort of 56 participants after a distance-trial of 60 min continuous swimming (age range from 14 to 22, 57.1% female). Cardiac troponin kinetics were modelled using Bayesian mixed-effects models to estimate time to peak (TTP) and peak concentration (PC) for each isoform, while controlling for participants sex, tanner stage and average relative heart rate during the test. Exercise induced an elevation of cTnT and cTnI in 93% and 75% of the participants, respectively. Cardiac troponin T peaked earlier, at 2.9 h (CI: 2.6 - 3.2 h) post-exercise, whereas cTnI peaked later, at 4.5 h (CI: 4.2 - 4.9 h). Peak concentrations for cTnT and cTnI were 2.5 ng/L, CI: 0 - 11.2 ng/L and 2.16 ng/L, CI: 0 - 22.7 ng/L, respectively. Additionally, we did not observe a systematic effect of sex and maturational status mediating cTn responses.
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Cirer-Sastre et al. (2022) studied this question.
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