Retrospective cohort study finds AEC and SII associated with CRS recurrence, suggesting predictive value for long-term outcomes.
Key Points
This study aims to identify CBC-derived biomarkers linked to the recurrence of chronic rhinosinusitis after sinus surgery.
Analyzed a retrospective cohort of 543 CRS patients undergoing endoscopic sinus surgery (ESS) using time-to-event methods.
Assessed CBC-derived biomarkers and clinical covariates, selecting variables with LASSO-penalized Cox regression followed by multivariable Cox modeling.
Evaluation of incremental prognostic value and changes over time.
254 patients (46.8%) experienced recurrence after surgery.
Higher absolute eosinophil count (AEC) (HR: 2.868) and systemic immune-inflammation index (SII) (HR: 1.320) were significantly linked to recurrence.
Adding AEC improved model discrimination significantly (C-index 0.778–0.797; p < 0.001), while SII showed minimal additional value.
Cite This Study
Kirtsreesakul et al. (2026) studied this question.