Preimplantation genetic testing and child health: a national register-based study

February 7, 2023Human ReproductionOpen Access

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Key Points

This study aims to assess the relationship between preimplantation genetic testing (PGT) and adverse perinatal and early childhood health outcomes.
Register-based study including 390 singletons born after PGT and 61,060 singletons born after IVF/ICSI from 1996 to 2019.
Comparisons made with matched samples born after spontaneous conception (42,034).
Logistic regression and Cox proportional hazards models were used for data analyses.
Preterm birth rates were 7.7% for PGT and 7.3% for IVF/ICSI, while low birthweight rates were 4.9% for PGT and 5.2% for IVF/ICSI.
Children after PGT showed a higher risk for preterm birth compared to spontaneous conception (AOR 1.73, 95% CI 1.17-2.58).
No significant differences detected in childhood health issues, with asthma rates at 9.7% for PGT and 11.4% for IVF/ICSI.

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Register-based study investigates perinatal and childhood health after preimplantation genetic testing, suggesting no adverse effects.

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Ernstad et al. (2023) studied this question.

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