Why the study?
Does the combination of cariporide and epinephrine improve resuscitation outcomes and reduce postresuscitation arrhythmias and myocardial dysfunction compared to epinephrine alone in a pig model of ventricular fibrillation?
Does the combination of cariporide and epinephrine improve resuscitation outcomes and reduce postresuscitation arrhythmias and myocardial dysfunction compared to epinephrine alone in a pig model of ventricular fibrillation?
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In a swine model of ventricular fibrillation, adding the NHE-1 inhibitor cariporide to epinephrine maintained adequate coronary perfusion pressure while preventing epinephrine-induced recurrent arrhythmias and myocardial dysfunction.
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Ayoub et al. (2005) studied this question.
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