Unlocking IL-18: A hidden key in cancer immunity

Shima Sepehri-Manesh; Marion Debeaud; Valérie Vouret‐Craviari

doi:10.1016/j.smim.2025.101997

October 6, 2025Seminars in ImmunologyOpen Access

Unlocking IL-18: A hidden key in cancer immunity

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Key Points

To review the biological functions of interleukin-18 (IL-18), originally identified as interferon-gamma-inducing factor, and elucidate its specific roles in modulating cancer immunity.
Narrative synthesis of published scientific literature examining the interleukin-1 (IL-1) cytokine family.
Evaluation of biological mechanisms and pathways mediated by IL-18 in the context of tumor immunology.
IL-18 operates within the broader IL-1 family to regulate diverse biological and inflammatory functions.
Acting as an interferon-gamma-inducing factor, IL-18 contributes directly to immune signaling pathways that impact antitumor responses.

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Implication

Review outlines the functional mechanisms of interleukin-18 in antitumor immunity, highlighting its therapeutic potential against cancer.

Abstract

1 cells. The IL-1 family members participated in various biological functions as described elsewhere in this special issue. Here, we provide an overview on IL-18, originally called IFN-γ inducing factor, and its role in impacting cancer immunity.

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Sepehri-Manesh et al. (2025) studied this question.

synapsesocial.com/papers/6a1bd7e00a1f7575939d099a https://doi.org/10.1016/j.smim.2025.101997

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Unlocking IL-18: A hidden key in cancer immunity

Key Points

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Implication

Abstract

Discussion

Cite This Study

Unlocking IL-18: A hidden key in cancer immunity

Key Points

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Implication

Abstract

Discussion

Cite This Study

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