What does this research mean for the field?

Catheter-based renal denervation achieves a reduction in blood pressure comparable to intensified pharmacotherapy including spironolactone in patients with true-resistant hypertension, while requiring fewer antihypertensive drugs. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 25, 2014HypertensionOpen Access

Randomized Comparison of Renal Denervation Versus Intensified Pharmacotherapy Including Spironolactone in True-Resistant Hypertension

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Why the study?

Does catheter-based renal denervation reduce blood pressure compared to intensified pharmacotherapy in patients with true-resistant hypertension?

Structured PICO

Does catheter-based renal denervation reduce blood pressure compared to intensified pharmacotherapy in patients with true-resistant hypertension?

Population

106 patients with true-resistant hypertension (confirmed by 24-hour ambulatory blood pressure monitoring after excluding secondary hypertension and confirmation of adherence to therapy by measurement of plasma antihypertensive drug levels before enrollment).

Intervention

Catheter-based renal denervation

Comparator

Intensified pharmacological treatment including spironolactone (if tolerated)

Outcome

Reduction in 24-hour average systolic blood pressure after 6 monthssurrogate

In patients with true-resistant hypertension, catheter-based renal denervation achieved comparable reductions in blood pressure to intensified pharmacotherapy including spironolactone at 6 months.

Discussion

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Implication

Renal denervation offers a non-drug alternative with comparable BP reduction to intensified pharmacotherapy; extends RCT evidence for device therapy in true-resistant hypertension.

Cite This Study

Rosa et al. (2014) studied this question.

synapsesocial.com/papers/6a1bdbebea84844e355f14b8 https://doi.org/10.1161/hypertensionaha.114.04019

Topics

Hypertension management

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Implication

Renal denervation offers a non-drug alternative with comparable BP reduction to intensified pharmacotherapy; extends RCT evidence for device therapy in true-resistant hypertension.

Randomized Comparison of Renal Denervation Versus Intensified Pharmacotherapy Including Spironolactone in True-Resistant Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Topics

Randomized Comparison of Renal Denervation Versus Intensified Pharmacotherapy Including Spironolactone in True-Resistant Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider