A B S T R A C T The erythropoietic effect of various thyroid hormones has been studied using erythroid colony formation by canine marrow cells. Although erythropoietin was required for colony growth, physiologic levels ofthyroid hormones significantly enhanced colony numbers. The order of potency of the thyroid compounds in their in vitro erythropoietic effect paral- lels their known calorigenic potency in vivo, suggesting that the in vitro effect is physiologically relevant. A series ofstudies linked the mechanism ofthyroid action to adrenergic receptors on responsive cells. Proprano- lol, a global ,8-blocker, inhibited thyroid hormone- responsive erythroid colonies. When adrenergic antag- onists having different blocking characteristics were added to culture, the thyroid hormone effect was blocked by those compounds having ,82-subspecificity.
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Popovic et al. (1977) studied this question.
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