Why the study?
Thermal PVI carries risk of collateral tissue injury, whereas PFA may ablate myocardium preferentially; randomized comparative data against conventional ablation were needed.
Does pulsed field ablation using a pentaspline catheter improve outcomes compared to conventional thermal ablation in patients with drug-resistant paroxysmal atrial fibrillation?
Population
Patients with drug-resistant PAF (adaptively determined sample size)
Comparison
PVI using PFA vs conventional thermal ablation (cryoballoon or radiofrequency)
Design
Multicenter, prospective, single-blind, randomized controlled noninferiority trial
Follow-up
12 months
Authors
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ADVENT RCT will deliver first randomized data on pulsed field versus thermal ablation in paroxysmal AF; extends evidence beyond observational reports.
Does pulsed field ablation using a pentaspline catheter improve outcomes compared to conventional thermal ablation in patients with drug-resistant paroxysmal atrial fibrillation?
The ADVENT trial is designed to evaluate the safety and efficacy of a novel pulsed field ablation system compared to standard-of-care thermal ablation for drug-resistant paroxysmal atrial fibrillation.
Reddy et al. (2023) studied this question.