Preclinical review reveals mechanisms linking plastic exposure to neurodegeneration in animal models, highlighting urgent implications for human neurological health and regulation.
Key Points
Synthesize preclinical animal evidence to clarify how plastic-derived chemicals and particles induce neurotoxicity and accelerate neurodegenerative disease pathways.
Reviewed experimental toxicology studies using rodent and zebrafish models exposed to plastics.
Evaluated neurotoxic agents including bisphenol A (BPA), phthalates, polybrominated diphenyl ethers (PBDEs), styrene, and micro- and nanoplastics.
Examined molecular mechanisms across varying exposure levels, developmental windows, and model systems.
Plastic particles and associated chemicals cross or compromise the blood-brain barrier across multiple preclinical models.