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Absolute regional cerebral blood volume (rCBV) was measured in vivo by the method of stimulated x-ray fluorescence of an iodinated contrast material. This is a noninvasive intravenous technique which allows the study of a volume of the brain approximately 1 cc in size. Initially, the method was validated in dogs and monkeys by demonstrating a good correlation between rCBV values obtained by fluorescence and rCBV values obtained with red blood cells labeled with radioactive chromium ( 51 Cr) in frozen, excised brain samples. Absolute regional cerebral blood volume was then measured in normal human volunteers, giving an average value of 3.20 cc/100 gm tissue.
Robert L. Grubb (Mon,) studied this question.