Why the study?
Does low-dose aspirin effectively inhibit platelet function compared to high-dose aspirin in type II hyperlipoproteinemic and normal subjects?
Population
30 subjects (18 type II hyperlipoproteinemic and 12 normal subjects)
Comparison
Low-dose aspirin and high-dose aspirin… vs Placebo
Design
Other
Follow-up
at least 10 days
Authors
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Comparable platelet inhibition by low- vs high-dose aspirin extends to hyperlipoproteinemia; leaves open effects on clinical events.
Does low-dose aspirin effectively inhibit platelet function compared to high-dose aspirin in type II hyperlipoproteinemic and normal subjects?
Low-dose aspirin (0.45 mg/kg/day) is as effective as high-dose aspirin (900 mg/day) in inhibiting platelet function, even in patients with type II hyperlipoproteinemia who were thought to have increased platelet reactivity.
M.L. Zucker (1986) studied this question.
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