Exploring Holography in Neuro-Vascular Dynamics

The holonomic brain theory—originally formulated to account for the need of non-local memory encoding in cognitive systems—could gain new theoretical traction when integrated with holographic principles from physics, most notably the AdS/CFT correspondence. Recent findings in neuroscience suggest that conformal field theories (CFTs), emerging at critical points across spatiotem-poral scales in neural dynamics, are essential for brain function. Concurrently, black-brane geometries, long studied in gravitational physics, can find unexpected analogues in the interplay of active matter dynamics and the brain’s neuroanatomical organization. Motivated by these parallels, we posit a generalized holographic framework and interrogate its validity through the fluid/gravity duality—a correspondence linking hydrodynamic equations to gravitational spacetime metrics. In this work, we explore the holographic principles at the Navier-Stokes regime, demonstrating that holography can model key neurophysiological mechanisms: cerebral autoregulation (the brain’s hemodynamic self-stabilization) and neurovascular coupling (the dynamic neuron-bloodflow interplay). This work bridges holography, active matter physics, and neuroscience, proposing a unified framework to decode the brain’s multiscale organization, its resilience to perturbations, and its computational capabilities. By grounding neurovascular physiology in gravitational duals, we open pathways to reinterpret brain function through the lens of emergent spacetime geometry.