What does this research mean for the field?

The adaptation of cardiac action potential duration to stimulation rate is driven by specific ionic mechanisms, particularly the late sodium current, and alterations in these mechanisms leading to intracellular sodium and calcium overload are critical in the genesis of arrhythmias in pathological conditions. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 21, 2006Journal of Cardiovascular ElectrophysiologyOpen Access

Action Potential Duration, Rate of Stimulation, and Intracellular Sodium

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Implication

No immediate practice changes for arrhythmias in HF or LQT; leaves open targeted late sodium current therapies for prospective validation.

Cite This Study

Edward Carmeliet (2006) studied this question.

synapsesocial.com/papers/6a1beef41567d2fc4d5f47b8 https://doi.org/10.1111/j.1540-8167.2006.00378.x

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Implication

No immediate practice changes for arrhythmias in HF or LQT; leaves open targeted late sodium current therapies for prospective validation.

Action Potential Duration, Rate of Stimulation, and Intracellular Sodium

Key Points

Discussion

Implication

Cite This Study

Action Potential Duration, Rate of Stimulation, and Intracellular Sodium

Key Points

Discussion

Implication

Cite This Study

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