Lisinopril-Induced “Scalded Mouth Syndrome”

OBJECTIVE: To report a case of "scalded mouth syndrome" (SMS) caused by lisinopril. PATIENT: A woman being treated with lisinopril for hypertension developed a burning sensation of her lips and buccal mucosa. The condition persisted with continued use of lisinopril and subsided when the medication was discontinued. CONCLUSIONS: The symptoms described by our patient were similar to those reported in previous cases of SMS associated with the use of enalapril and captopril, two other angiotensin-converting enzyme (ACE) inhibitors. This reaction to ACE inhibitors appears to be dose related, and subsides with a decreased dosage or discontinuation of the medication.