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July 4, 2014Annals of Neurology

Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide

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Authors

ECEmanuela ColomboVita-Salute San Raffaele UniversityMDMarco Di DarioJohn Innes CentreECEleonora CapitoloVita-Salute San Raffaele University

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Colombo et al. (2014) studied this question.

synapsesocial.com/papers/6a1bf66f1567d2fc4d5f5556https://doi.org/10.1002/ana.24217
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration2012 · 144 citations
  2. 2Transgenic Inhibition of Astroglial NF-κB Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation2009 · 265 citations
  3. 3FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P <sub>1</sub> ) modulation2010 · 581 citations