Does intravenous esmolol reduce blood pressure in patients with hypertensive crisis during pre-hospital emergency care?
Intravenous esmolol provides rapid and significant blood pressure reduction in the pre-hospital management of hypertensive crises.
In 94 patients, suffering from complicated or uncomplicated hypertensic crisis, the efficiency and safety of esmolol administration in pre-hospital stage of emergency medical care was examined. Unique pharmacokinetics of esmolol allow us to achieve significant arterial tension decrease during the first minutes of the intravenous injection, meanwhile antihypertensive effect increases till 20 minutes and elimination half-life is 9 minutes. Esmolol dosage was selected depending on initial hemodynamic indicators and hypertensic crisis complications. In order to evaluate efficiency and safety in this research the following indicators were measured: sistolic blood pressure, diastolic blood pressure, heart rate, electrocardiogram and SpO 2 , respiratory function monitoring.
Н. И. Гапонова (2023) studied this question.