What does this research mean for the field?

Regional differences in myocardial oxygenation create an electrical current across the contact zone that causes electric instability and triggers ventricular fibrillation, whereas uniformly oxygenated or uniformly anoxic hearts remain electrically stable. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Investigate how variations in myocardial oxygenation cause electrical instability and precipitate ventricular fibrillation.

February 1, 1956CirculationOpen Access

Electric Instability of the Heart

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Why the study?

Does a regional oxygen differential in the myocardium cause electric instability and ventricular fibrillation in dog hearts?

Population

Dog hearts (normally oxygenated and uniformly anoxic models)

Comparison

Creation of regional myocardial ischemia or… vs Uniformly oxygenated or uniformly anoxic…

Design

Preclinical

Authors

BBBernard L. BrofmanMount Sinai Hospital DLDavid S. LeighningerUniversity Hospitals of Cleveland CBClaude S. BeckHarvard University

Discussion

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Implication

Regional oxygen gradients may promote arrhythmias in ischemia; leaves open relevance to human VF mechanisms.

Key Points

Investigate how variations in myocardial oxygenation cause electrical instability and precipitate ventricular fibrillation.
Assessed resting electric potentials and incidence of spontaneous ventricular fibrillation in canine hearts under uniform oxygenation and uniform anoxia.
Introduced regional myocardial ischemia or regional oxygenated perfusion into uniformly anoxic hearts to evaluate electrical boundary effects.
Uniformly oxygenated and uniformly anoxic hearts exhibited electrical stability, demonstrating equivalent resting electric potentials and zero spontaneous ventricular fibrillation.
An oxygen gradient created at the contact zone between ischemic and oxygenated myocardium triggered marked electrical instability and destroyed coordinated cardiac rhythm.
Perfusion of oxygenated blood into an otherwise uniformly anoxic heart produced a reverse trigger, similarly resulting in electric instability.

Structured PICO

Does a regional oxygen differential in the myocardium cause electric instability and ventricular fibrillation in dog hearts?

Population

Dog hearts (normally oxygenated and uniformly anoxic models)

Intervention

Creation of regional myocardial ischemia or regional perfusion with oxygenated blood in an anoxic heart (creating an oxygen differential)

Comparator

Uniformly oxygenated or uniformly anoxic myocardium

Outcome

Electric instability (resting electric potentials and spontaneous ventricular fibrillation)surrogate

Regional differences in myocardial oxygenation, rather than uniform anoxia, are the primary trigger for electrical instability and ventricular fibrillation.

Cite This Study

Brofman et al. (1956) studied this question.

synapsesocial.com/papers/6a1bf7fc1567d2fc4d5f5837 https://doi.org/10.1161/01.cir.13.2.161

Topics

Coronary artery disease

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Electric Instability of the Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Electric Instability of the Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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