Species differences in lipoprotein lipase and hepatic lipase activities: comparative studies of animal models of lifestyle-related diseases

Figures

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  Fig. 1.. Changes in lipoprotein lipase (LPL) (open circles) and hepatic triglyceride lipase (HTGL) (solid circles) activities after heparin intravenous injection in various animals. The animals used were female mice and rats, and male rabbits. Data are mean ± SEM. Statistical analyses between LPL and HTGL activities were performed by the Student’s t-test (*P<0.05; **P<0.01; ***P<0.001).

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  Fig. 2.. Lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) activities in each animal species at fasting (open bars) and feeding (solid bars). Lipase activities were measured using plasma obtained 5 min (mice) or 15 (rats and rabbits) min after heparin intravenous injection. Data are mean ± SEM. Statistical analyses between fasting and feeding were performed by Paired t-test.

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  Fig. 3.. Lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) activities in normal (open bars) and mutant (solid bars) animals. Lipase activities were measured using plasma obtained 5 min (mice) or 15 min (rats and rabbits) after heparin intravenous injection. Animals used in this experiment are females in mice and rats, and males in rabbits. Data are mean ± SEM. Statistical analyses between normal and mutant animals were performed by the Student’s t-test.

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  Fig. 4.. Lipoprotein triglyceride levels before (open bars) and after (solid bars) heparin injection. Post-heparin plasma was obtained 5 (mice) or 15 (rats and rabbits) min after heparin intravenous injection. Lipoproteins were fractionated by HPLC (Skylight Biotech Inc.) The numerical values are the rates of change before heparin injection. Data are mean ± SEM. Statistical analyses before and after the heparin injection were performed with a paired t-test.

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  Fig. 5.. Relationship between lipase activity and rates of lipoprotein triglyceride reductions in WHHLMI rabbits. R2, correlation coefficient.