Key result
Percutaneous endomyocardial injection using real-time MRI guidance was feasible in a porcine model, achieving an 81% success rate across more than 50 injections.
Why the study?
Is targeted left ventricular mural injection feasible using real-time MRI guidance in a pig model?
Population
Pigs undergoing targeted left ventricular mural injection
Design
Preclinical
Authors
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Does not support clinical use; leaves open translation of MRI-guided LV delivery to humans.
Is targeted left ventricular mural injection feasible using real-time MRI guidance in a pig model?
Percutaneous endomyocardial drug delivery is feasible with the aid of real-time MRI, allowing precise 3-dimensional localization within the left ventricular wall.
Lederman et al. (2002) studied this question. Catheter-based endomyocardial injection with real-time MRI was evaluated on Successful endomyocardial injections. Percutaneous endomyocardial injection using real-time MRI guidance was feasible in a porcine model, achieving an 81% success rate across more than 50 injections.
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