Percutaneous endomyocardial injection using real-time MRI guidance was feasible in a porcine model, achieving an 81% success rate across more than 50 injections.
Background — We tested the feasibility of targeted left ventricular (LV) mural injection using real-time MRI (rtMRI). Methods and Results — A 1.5T MRI scanner was customized with a fast reconstruction engine, transfemoral guiding catheter–receiver coil (GCC), MRI-compatible needle, and tableside consoles. Commercial real-time imaging software was customized to facilitate catheter navigation and visualization of injections at 4 completely refreshed frames per second. The aorta was traversed and the left ventricular cavity was entered under direct rtMRI guidance. Pigs underwent multiple injections with dilute gadolinium-DTPA. All myocardial segments were readily accessed. The active GCC and the passive Stiletto needle injector were readily visualized. More than 50 endomyocardial injections were performed with the aid of rtMRI; 81% were successful with this first-generation prototype. Conclusion — Percutaneous endomyocardial drug delivery is feasible with the aid of rtMRI, which permits precise 3-dimensional localization of injection within the LV wall.
Lederman et al. (Tue,) reported a other. Catheter-based endomyocardial injection with real-time MRI was evaluated on Successful endomyocardial injections. Percutaneous endomyocardial injection using real-time MRI guidance was feasible in a porcine model, achieving an 81% success rate across more than 50 injections.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: