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Aucubin, an iridoid glucoside isolated from Aucuba japonica (Cornaceae), exhibited significant protective activity against alpha-amanitin intoxication in mice. When a single dose of aucubin was administered intraperitoneally, a 50% survival rate was obtained even when the treatment was withheld for 12 hr after alpha-amanitin administration. A possible mechanism of protective activity is partly due to a competitive effect of aucubin on alpha-amanitin inhibition of liver RNA biosynthesis.
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Chang et al. (1984) studied this question.
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