Key result
A 1-SD increase in the general depression factor was associated with a 25% increased risk of all-cause mortality (HR 1.25) following myocardial infarction, independent of somatic symptoms.
Why the study?
Is a general depression factor associated with adverse medical prognosis following myocardial infarction independent of somatic symptoms?
Meta-Analysis (n=7,595)
Yes
Is a general depression factor associated with adverse medical prognosis following myocardial infarction independent of somatic symptoms?
Effect estimate: HR 1.25 (95% CI 1.17-1.34)
p-value: p=<0.001
A general depression factor is independently associated with increased risk of all-cause mortality and cardiovascular events following myocardial infarction, even after accounting for somatic symptoms.
May inform post-MI risk stratification beyond somatic symptoms; supports targeted research on affective depression components.
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Azevedo et al. (2016) conducted a meta-analysis in Myocardial infarction (n=7,595). General depression factor (per 1-SD increase) was evaluated on All-cause mortality (HR 1.25, 95% CI 1.17-1.34, p=<0.001). A 1-SD increase in the general depression factor was associated with a 25% increased risk of all-cause mortality (HR 1.25) following myocardial infarction, independent of somatic symptoms.
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