Female gender was associated with a 20% increased adjusted risk of in-hospital composite events (OR 1.20) compared to men in patients undergoing percutaneous coronary intervention.
Observational (n=44,967)
Sí
Does female gender increase the risk of in-hospital mortality and composite events in patients undergoing PCI in the drug-eluting stent era?
In the contemporary drug-eluting stent era, women undergoing PCI have a higher risk of in-hospital composite events compared to men, though in-hospital mortality risk is similar after adjusting for baseline differences.
Estimación del efecto: Adjusted OR 1.20 (95% CI 1.05-1.37)
Tasa de eventos absoluta: 7.01% vs 5.48%
valor p: p=0.008
Most studies on gender difference of the in-hospital outcome of percutaneous coronary intervention (PCI) were performed in the pre-drug-eluting stents (DES) era. This study was performed to investigate whether gender influences the in-hospital outcome of PCI in the DES era.A total of 44,967 PCI procedure between January and December of 2014 from the nationwide PCI registry database in Korea were analyzed. The study population was male predominant (70.2%). We examined the association of gender with unadjusted and adjusted in-hospital mortality and composite events of PCI, including mortality, nonfatal myocardial infarction, stent thrombosis, stroke, urgent repeat PCI and bleeding requiring transfusion.Most of the study patients (91.3%) received DES. The incidence rates of in-hospital mortality (2.95% vs 1.99%, P <.001) and composite events (7.01% vs 5.48%, P <.001) were significantly higher in women compared to men. Unadjusted analyses showed that women had a 1.49 times higher risk of in-hospital mortality and a 1.30 times higher risk of composite events than men (P <.001 for each). After adjustment for potential confounders, female gender was not a risk factor for mortality (P = .258), but the risk of composite events remained 1.20 times higher in women than in men (P = .008).Among patients undergoing PCI in the contemporary DES era, female gender was associated with an increased risk of in-hospital composite events, but not in-hospital mortality. More careful attention should be emphasized to minimize procedure-related risks and to improve prognosis in women undergoing PCI.
Kim et al. (Wed,) conducted a observational in Coronary artery disease requiring percutaneous coronary intervention (n=44,967). Female gender vs. Male gender was evaluated on In-hospital composite events (mortality, nonfatal myocardial infarction, stent thrombosis, stroke, urgent repeat PCI, and bleeding requiring transfusion) (Adjusted OR 1.20, 95% CI 1.05-1.37, p=0.008). Female gender was associated with a 20% increased adjusted risk of in-hospital composite events (OR 1.20) compared to men in patients undergoing percutaneous coronary intervention.