What does this research mean for the field?

Among individuals aged 70-95 years, 76.1% have LDL-cholesterol levels ≥116 mg/dL, and high HbA1c or extremes in blood pressure are significantly associated with impaired kidney function. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 7, 2023Journal of Clinical MedicineOpen Access

Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study

Q: What are the key findings of this study?

In community-dwelling adults aged 70-95 years, low systolic blood pressure (<120 mmHg) was significantly associated with an increased risk of impaired eGFR (OR 1.274), predominantly among those taking diuretics.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Cardiovascular risk factors and impaired kidney function (n=2215). Intervention: Low systolic blood pressure (<120 mmHg) vs. Normal/achieved systolic blood pressure (120-140 mmHg). Primary outcome: Impaired creatinine-based estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2) (OR 1.274, p=0.045).

View Full Paper

Ask AI

Bookmark

Key result

Low SBP under 120 mmHg linked to ~27% higher risk of impaired eGFR in older adults.

OR 1.274
P=0.045
n=2,215

Why the study?

Population-based data on the extent of cardiovascular risk factor control in the old-aged population are limited despite high glucose, LDL-cholesterol, blood pressure, and impaired kidney function being particularly frequent.

Population

2215 mobile individuals aged 70-95 years of/near Regensburg

Comparison

Cardiovascular risk factors within vs beyond recommended levels

Design

Population-based cross-sectional cohort study

Authors

FDFerdinand J. Donhauser MZMartina E. ZimmermannUniversity of Regensburg ASAnna B. Steinkirchner

Discussion

Member takes

Implication

Low SBP associated with eGFR impairment in elderly on diuretics; leaves open whether BP targets warrant age-specific adjustment.

Study Design

Type

Cross-Sectional (n=2,215)

Multicenter

Structured PICO

Population

2,215 mobile, community-dwelling older adults aged 70 to 95 years from Germany, assessed cross-sectionally for cardiovascular risk factor control and concurrent kidney function impairment.

Outcome

Proportion of participants with LDL-cholesterol, HbA1c, or blood pressure beyond recommended levels and their association with impaired creatinine- and cystatin-based estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2) or urine albumin-creatinine ratio (UACR ≥30 mg/g).surrogate

Main Result

Odds Ratio: 1.274

p-value: p=0.045

In a mobile elderly population aged 70-95 years, cardiovascular risk factor control is highly variable, with poor LDL-cholesterol control but excellent HbA1c control, and low blood pressure is associated with impaired eGFR, particularly among those on diuretics.

Limitations

Cross-sectional design limits causal interpretation and determination of the sequence of events.
Selection bias, as the study captures a physically mobile and mentally healthy population able to visit the study center.
Medication dosages were not ascertained, limiting the ability to assess dose-dependent effects.
Self-reported heart failure was unreliable and therefore not adjusted for in the analyses.
Cross-sectional design limits interpretation regarding the sequence of events and causality.
Selection bias, as the study captures a physically mobile and mentally healthy population over 70 years of age able to visit the study center.
Self-reported heart failure was unreliable and not adjusted for.
Dosages of medication intake were not ascertained.

Cite This Study

Donhauser et al. (2023) conducted a cross-sectional in Cardiovascular risk factors and impaired kidney function (n=2,215). Low systolic blood pressure (<120 mmHg) vs. Normal/achieved systolic blood pressure (120-140 mmHg) was evaluated on Impaired creatinine-based estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2) (OR 1.274, p=0.045). In community-dwelling adults aged 70-95 years, low systolic blood pressure (<120 mmHg) was significantly associated with an increased risk of impaired eGFR (OR 1.274), predominantly among those taking diuretics.

synapsesocial.com/papers/6a1c07746f692abb725f0ae3 https://doi.org/10.3390/jcm12062102

View Full Paper

Ask AI

Bookmark

March 7, 2023Journal of Clinical MedicineOpen Access

Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study

View Full Paper

Ask AI

Bookmark

Key result

Low SBP under 120 mmHg linked to ~27% higher risk of impaired eGFR in older adults.

OR 1.274
P=0.045
n=2,215

Why the study?

Population

2215 mobile individuals aged 70-95 years of/near Regensburg

Comparison

Cardiovascular risk factors within vs beyond recommended levels

Design

Population-based cross-sectional cohort study

Authors

FDFerdinand J. Donhauser MZMartina E. ZimmermannUniversity of Regensburg ASAnna B. Steinkirchner

Discussion

Member takes

Implication

Low SBP associated with eGFR impairment in elderly on diuretics; leaves open whether BP targets warrant age-specific adjustment.

Study Design

Type

Cross-Sectional (n=2,215)

Multicenter

Structured PICO

Population

2,215 mobile, community-dwelling older adults aged 70 to 95 years from Germany, assessed cross-sectionally for cardiovascular risk factor control and concurrent kidney function impairment.

Outcome

Main Result

Odds Ratio: 1.274

p-value: p=0.045

Limitations

Cross-sectional design limits causal interpretation and determination of the sequence of events.
Selection bias, as the study captures a physically mobile and mentally healthy population able to visit the study center.
Medication dosages were not ascertained, limiting the ability to assess dose-dependent effects.
Self-reported heart failure was unreliable and therefore not adjusted for in the analyses.
Cross-sectional design limits interpretation regarding the sequence of events and causality.
Selection bias, as the study captures a physically mobile and mentally healthy population over 70 years of age able to visit the study center.
Self-reported heart failure was unreliable and not adjusted for.
Dosages of medication intake were not ascertained.

Cite This Study

synapsesocial.com/papers/6a1c07746f692abb725f0ae3 https://doi.org/10.3390/jcm12062102

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark