Key result
Semi-automated CMR segmentation at 30% threshold matches manual contouring and phase-contrast flow for biventricular volumes.
Why the study?
Automatic detection of myocardial contours on CMR images using signal thresholding techniques requires validation before use in clinical settings.
Does semi-automated threshold-based CMR segmentation accurately measure ventricular volumes and cardiac index compared to manual segmentation and flow measurements in young patients with various cardiac diseases?
Cross-Sectional (n=94)
No
Does semi-automated threshold-based CMR segmentation accurately measure ventricular volumes and cardiac index compared to manual segmentation and flow measurements in young patients with various cardiac diseases?
A 30% signal intensity threshold for semi-automated CMR segmentation provides accurate and reproducible ventricular volume measurements comparable to manual tracing in young patients with diverse cardiac pathologies.
May support 30% threshold semi-automated segmentation for CMR volumes in young patients; leaves open prospective validation across scanners and populations.
In many cardiac diseases, right and left ventricular volumes in systole and diastole are diagnostically and prognostically relevant. Measurements are made by segmentation of the myocardial borders on cardiac magnetic resonance (CMR) images. Automatic detection of myocardial contours is possible by signal thresholding techniques, but must be validated before use in clinical settings. Biventricular volumes were measured in end-diastole (EDVi) and in end-systole (ESVi) both manually and with the MassK application, with signal thresholds at 30%, 50%, and 70%. Stroke volumes (SV) and cardiac indices (CI) were calculated from volumetric measurements and from flow measured in the ascending aorta and the main pulmonary artery, and both methods were compared. Reproducibility of volumetric measurements was tested in 20 patients. Measurements were acquired in 94 patients aged 15 ± 9 years referred for various conditions. EDVi and ESVi of both ventricles were largest with manual segmentation and inversely proportional to the MassK threshold. Manual and k30 SV and CI corresponded best to flow measurements. Interobserver variability was low for all volumes manually and with MassK. In conclusion, manual and 30% threshold-based biventricular volume segmentation agree best with two-dimensional, phantom-corrected phase contrast flow measurements in a young cardiac referral population and are well reproducible.
No takes yet. Share an insight, caveat, or question.
Thut et al. (2023) conducted a cross-sectional in Various cardiac diseases and congenital heart disease (n=94). Semi-automated threshold-based segmentation (MassK) vs. Manual contour-based segmentation and 2D phase contrast flow measurements was evaluated on Accuracy of ventricular stroke volume and cardiac index compared to 2D phase contrast flow measurements. Semi-automated threshold-based segmentation at a 30% signal intensity threshold and manual segmentation agreed best with 2D phase contrast flow measurements for biventricular volumes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: