What is the clinical evidence from this study?

Study design: Other. Population: Arterial stenosis. Intervention: Numerical simulation of blood flow. Primary outcome: Flow fluctuations, Wall Shear Stress (WSS), and Oscillatory Shear Index (OSI).

January 13, 2025Scientific Reports16 citationsOpen Access

Study of blood flow patterns in a stenosed artery through the combined effect of body acceleration and generalized womersley solution

Q: What does this research mean for the field?

Exercise conditions and rapid transitions from resting to exercise states increase flow recirculation and oscillatory shear index downstream of arterial stenoses. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

MUMahesh C. Udupa SSSunanda Saha SNSekarapandian Natarajan

Resultado clave

Numerical simulations demonstrated that exercise conditions and rapid transitions from resting to exercise states increase flow recirculation and oscillatory shear index downstream of arterial stenoses.

PICO estructurado

Población

Computational model of a stenosed artery (idealized models based on a healthy internal carotid artery) simulating blood flow under realistic physiological conditions (resting and exercise) and external body acceleration.

Intervención

Numerical simulation using a modified two-dimensional SIMPLE pressure-correction-based solver with orthogonal coordinate transformation, generalized Womersley solution at the inlet, and a generalized power-law fluid model for blood rheology.

Resultado

Flow fluctuations, time-averaged and phase-averaged data, recirculation downstream of the stenosis, and wall shear stress (WSS) / oscillatory shear index (OSI).surrogate

Numerical simulations demonstrate that exercise increases recirculation downstream of arterial stenosis and that the transition rate between resting and exercise conditions correlates with stenosis development, highlighting potential hemodynamic complications.

Limitaciones

The study assumes a two-dimensional axisymmetric flow.
The model uses one-way coupling of blood flow, meaning the pressure gradient does not influence the compliance of the wall (rigid walls).
The study uses idealized models of stenosed vessels rather than patient-specific geometries.

Resumen

Abstract Stenosis causes the narrowing of arteries due to plaque buildup, which impedes blood flow and affects flow dynamics. This work numerically analyzes flow fluctuations in stenosed arteries under realistic physiological conditions (resting and exercise) and external body acceleration. The artery is inclined at angle Θ, and blood rheology is modeled using a generalized power-law fluid. A modified two-dimensional SIMPLE pressure-correction-based numerical solver with orthogonal coordinate transformation simulates blood flow. A generalized Womersley solution is imposed at the inlet. We validate the solver and perform simulations to assess the influence of geometric and flow parameters, analyzing time-averaged and phase-averaged data. We investigate the correlation between hyperviscosity and physiological conditions, finding that exercise increases recirculation downstream of the stenosis. We also study the impact of transitioning between resting and exercise conditions, noting that the transition rate correlates with stenosis development, indicating potential complications.

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Cite This Study

Udupa et al. (Mon,) conducted a other in Arterial stenosis. Numerical simulation of blood flow was evaluated on Flow fluctuations, Wall Shear Stress (WSS), and Oscillatory Shear Index (OSI). Numerical simulations demonstrated that exercise conditions and rapid transitions from resting to exercise states increase flow recirculation and oscillatory shear index downstream of arterial stenoses.

synapsesocial.com/papers/6a1c0b0826cb5670aa9d4abd https://doi.org/https://doi.org/10.1038/s41598-025-85566-2

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