What does this research mean for the field?

In rabbit sino-atrial node cells, outward-going rectification is driven by increased potassium conductance, whereas inward-going rectification is accompanied by decreased membrane resistance and likely involves combined changes in sodium, chloride, and potassium conductances. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1976The Journal of PhysiologyOpen Access

Characteristics of the rectifying properties of the sino‐atrial node cell of the rabbit.

View Full Paper

Ask AI

Bookmark

Population

Sino-atrial (S-A) node cells from rabbit hearts (man-made strands including the pacemaker region)

Design

Preclinical

Authors

ISIssei SeyamaNorthwestern University

Discussion

Member takes

Implication

Rabbit SAN rectification data extend pacemaker ion channel mapping; leaves open translation to human nodal electrophysiology.

Structured PICO

Population

Sino-atrial (S-A) node cells from rabbit hearts (man-made strands including the pacemaker region)

Intervention

Current-clamp and voltage-clamp experiments using the single sucrose gap method

Outcome

Rectifying properties (outward-going and inward-going rectification)surrogate

This preclinical study characterizes the outward and inward rectifying properties of rabbit sino-atrial node cells, suggesting involvement of K, Na, and Cl conductances.

Cite This Study

Issei Seyama (1976) studied this question.

synapsesocial.com/papers/6a1c0cc44ebd09f3dfa960f9 https://doi.org/10.1113/jphysiol.1976.sp011285

View Full Paper

Ask AI

Bookmark

Characteristics of the rectifying properties of the sino‐atrial node cell of the rabbit.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characteristics of the rectifying properties of the sino‐atrial node cell of the rabbit.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider