Why the study?
Do MAPSE and TAPSE measured by MRI correlate with conventional LVEF, RVEF, and NTproBNP in patients with dilated cardiomyopathy?
Do MAPSE and TAPSE measured by MRI correlate with conventional LVEF, RVEF, and NTproBNP in patients with dilated cardiomyopathy?
The study aims to determine if MRI-derived MAPSE and TAPSE can serve as simpler, faster alternatives to conventional EF assessment by correlating them with EF and NT-proBNP in dilated cardiomyopathy.
MRI MAPSE/TAPSE correlations with EF/NT-proBNP in dilated cardiomyopathy are hypothesis-generating; prospective outcome studies needed before considering EF alternatives.
Background MRI is the current reference-standard for quantification of systolic left and right ventricular (LV/RV-) function. However, the conventional three-dimensional quantitative assessment of LV and RV-ejection fraction (EF), is time consuming and operator-dependant. The mitral/tricuspid annular plane systolic excursion (MAPSE/TAPSE) towards the apex, on the other hand, can be easily and promptly quantified on MR-images and has been previously shown to, correlate with LVand RVEF and with the prognosis of patients with heart failure in echocardiographic studies. The aim of this study was to compare the value of MAPSE and TAPSE to the conventional LVEF and RVEF assessment and to the well established biomarker NTproBNP in heart failure.
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Loßnitzer et al. (2008) studied this question.
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