Key result
Cancer diagnosis linked to ~4% higher cerebrovascular mortality, peaking within two months.
Why the study?
The risk of subsequent cerebrovascular disease among patients across multiple cancer types in the US was not well understood.
Does cancer diagnosis increase the risk of cerebrovascular disease mortality in the US population?
Cohort (n=3,843,261)
Yes
Does cancer diagnosis increase the risk of cerebrovascular disease mortality in the US population?
Cancer patients have a slightly elevated overall risk of cerebrovascular disease mortality compared to the general population, with the highest risk occurring within the first two months after diagnosis and varying significantly by cancer type.
May warrant early cerebrovascular monitoring after cancer diagnosis; leaves open causality and need for targeted prevention trials.
The risk of subsequent cerebrovascular disease among cancer patients of multiple cancers in the US is not well understood. A total of 3,843,261 cancer patients diagnosed from 1975 to 2018, were included from the surveillance, epidemiology, and end results (SEER) database. Standardized mortality ratios (SMRs) and absolute excess risks (AERs) were estimated. The overall cerebrovascular disease SMR was 1.04 (95% CI, 1.03-1.04), and the AER per 10,000 person-years at risk was 0.89. When compared with the US general population, greater cerebrovascular disease risk was correlated with certain cancer sites, American Indian/Alaska Native race, Asian or Pacific Islander race, unmarried marital status, distant metastasis, younger age, and an earlier time of cancer diagnosis. Clinically, more precision and proactive strategies for cerebrovascular disease prevention are required to subgroup of cancer patients with a greater risk of cerebrovascular disease, especially within the first two months.
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Liu et al. (2023) conducted a cohort in Cancer (n=3,843,261). Cancer diagnosis vs. US general population was evaluated on Cerebrovascular disease mortality (SMR 1.04, 95% CI 1.03-1.04). Cancer diagnosis was associated with a slightly increased risk of cerebrovascular disease mortality compared to the general US population (SMR 1.04), with the highest risk occurring in the first two months after diagnosis.
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