Why the study?
Does acute pharmacological sGC stimulation with BAY 41-8543 increase LV capacitance via titin phosphorylation in healthy and DOCA-induced hypertensive pigs?
Population
9 healthy Landrace pigs and 7 pigs with deoxycorticosteroneacetate-induced hypertension and LV concentric…
Comparison
Intravenous infusion of BAY 41-8543 vs Baseline (before infusion)
Design
Preclinical
Follow-up
30 min
Key result
Acute pharmacological stimulation of soluble guanylate cyclase with BAY 41-8543 did not increase left ventricular compliance in normal and hypertrophied porcine hearts.
Authors
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Does not support acute sGC stimulation to improve LV compliance; leaves open whether titin phosphorylation affects capacitance in other models or species.
Does acute pharmacological sGC stimulation with BAY 41-8543 increase LV capacitance via titin phosphorylation in healthy and DOCA-induced hypertensive pigs?
Acute pharmacological stimulation of soluble guanylate cyclase does not increase left ventricular compliance in normal and hypertrophied porcine hearts, indicating that increased titin phosphorylation does not necessarily translate to increased in vivo LV capacitance.
Alogna et al. (2018) studied Healthy and DOCA-induced hypertension with LV concentric hypertrophy (n=34). BAY 41-8543 vs. Baseline was evaluated on Left ventricular end-diastolic pressure-volume relationships (EDPVRs). Acute pharmacological stimulation of soluble guanylate cyclase with BAY 41-8543 did not increase left ventricular compliance in normal and hypertrophied porcine hearts.