Key result
High central pulse pressure linked to higher 30-day mortality in COVID-19 viral pneumonia.
Why the study?
COVID-19 viral pneumonia can increase arterial stiffness alongside cardiac and systemic inflammatory responses, but the associations between arterial stiffness, inflammation severity, and all-cause mortality needed investigation.
Does high central arterial pulse pressure predict all-cause mortality in patients with COVID-19 viral pneumonia?
Cohort (n=106)
No
Does high central arterial pulse pressure predict all-cause mortality in patients with COVID-19 viral pneumonia?
High central arterial pulse pressure (CAPP ≥ 50 mm Hg) is an independent predictor of all-cause mortality in patients with COVID-19 viral pneumonia.
Answers are grounded in this paper and cite their sources.
High CAPP may aid mortality risk stratification in COVID-19 pneumonia; leaves open independent prognostic value pending prospective validation.
OBJECTIVES: COVID-19 viral pneumonia can result in increased arterial stiffness, along with cardiac and systemic inflammatory responses. This study aimed to investigate the association between arterial stiffness, inflammation severity, and all-cause mortality in patients with COVID-19. METHODS: In this study, anthropometric data, pneumonia infection severity, and blood tests were analyzed. Arterial stiffness was assessed using the non-invasive assessment indices, including arterial velocity pulse index (AVI) and central arterial pulse pressure (CAPP). Infection volumes and percentages for the whole lungs, most lobes, and most segments were extracted from CT images using artificial intelligence-based quantitative analysis software. The relationship between arterial stiffness, central hemodynamics, and all-cause mortality was investigated. RESULTS: In multivariable Cox regression analysis, high CAPP was significantly associated with all-cause mortality (hazard ratio: 0.263, 95% CI, 0.073-0.945, p = 0.041). Whole lung infection percentages were independently associated with high CAPP, with an area under the curve (AUC) of 0.662 and a specificity of 89.09%. CONCLUSIONS: High CAPP, but not high AVI, demonstrated independent prognostic value for all-cause mortality in patients due to COVID-19 pneumonia infection. Evaluating this parameter could help in risk assessment and improve diagnostic and therapeutic strategies in viral pneumonia infections.
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Jin et al. (2024) conducted a cohort in COVID-19 viral pneumonia (n=106). High central artery pulse pressure (CAPP ≥ 50 mm Hg) vs. Normal CAPP (< 50 mm Hg) was evaluated on 30-day mortality (HR 0.263, 95% CI 0.073-0.945, p=0.041). High central artery pulse pressure (≥ 50 mm Hg) was significantly associated with an increased risk of all-cause mortality in patients with COVID-19 viral pneumonia (HR 0.263).
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