Key result
Low subendocardial viability ratio is linked to ~132% higher all-cause mortality, predominantly in men.
Why the study?
Low subendocardial viability ratio (SEVR) predicts mortality in kidney disease and diabetes, but its association with mortality in the elderly population required investigation.
Does a low subendocardial viability ratio (SEVR ≤130%) predict all-cause and cardiovascular mortality in an elderly population?
Cohort (n=1,414)
Does a low subendocardial viability ratio (SEVR ≤130%) predict all-cause and cardiovascular mortality in an elderly population?
Effect estimate: HR 3.52 (95% CI 1.31-9.46)
Subendocardial viability ratio (SEVR) is an age- and sex-dependent predictor of all-cause mortality, showing strong predictive value in men younger than 60 years but losing significance in older populations.
Low SEVR was associated with mortality mainly in men <60 years; leaves open its prognostic value in elderly cohorts.
OBJECTIVES: The subendocardial viability ratio (SEVR) reflects the balance of myocardial oxygen supply and demand. Low SEVR indicates a reduced subendocardial perfusion and has been shown to predict mortality in patients with kidney disease and diabetes. The aim of this study is to investigate the association of SEVR and mortality in the elderly population. METHODS: We analysed data from the CARdiovascular disease, Living and Ageing in Halle (CARLA) study. SEVR was estimated noninvasively by radial artery tonometry and brachial blood pressure measurement. The study population was divided into a low (SEVR ≤130%) and normal (SEVR >130%) SEVR group. Cox-regression was used for survival analysis. RESULTS: In total, 1414 participants (635 women, 779 men) aged from 50 to 87 years (mean age 67.3 years) were included in the analysis. The all-cause mortality was 22.7% during a median follow-up of 10.5 years. The unadjusted association of SEVR with all-cause mortality decreased from 3.52 (1.31-9.46) [hazard ratio (95% confidence interval) for low SEVR ≤ 130% versus normal SEVR > 130%] among those younger than 60 years to 0.86 (0.50-1.48) among those older than 80 years and from 1.81 (0.22-14.70) to 0.75 (0.30-1.91) for cardiovascular mortality. Sex-specific unadjusted analyses demonstrated an association of SEVR with all-cause and cardiovascular mortality in men [2.32 (1.61-3.34) and 2.24 (1.18-4.24)], but not in women [1.53 (0.87-2.72) and 1.14 (0.34-3.82)]. CONCLUSION: Our data suggests that SEVR is an age dependent predictor for all-cause mortality, predominantly in men younger than 60 years.
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Schott et al. (2023) conducted a cohort in Elderly population (n=1,414). Low subendocardial viability ratio (SEVR ≤130%) vs. Normal SEVR (>130%) was evaluated on All-cause mortality (HR 3.52, 95% CI 1.31-9.46). Low subendocardial viability ratio (≤130%) was associated with increased all-cause mortality, predominantly in men (HR 2.32; 95% CI 1.61-3.34) and participants <60 years (HR 3.52; 95% CI 1.31-9.46).
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