Perioperative Period is a Critical Gap for Minimal Residual Cancer Cells Progression and Therapy: Biological and Molecular Based Evidences

Anwar Tawfik Amin; Norio Shiraishi; Seigo Kitano

doi:10.14302/issn.2372-6601.jhor-18-2396

October 4, 2018Journal of Hematology and Oncology ResearchOpen Access

Perioperative Period is a Critical Gap for Minimal Residual Cancer Cells Progression and Therapy: Biological and Molecular Based Evidences

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Key Points

To review the biological, microenvironmental, and immunological mechanisms triggered during the perioperative window that facilitate minimal residual cancer progression and evaluate potential therapeutic interventions.
Synthesized molecular and cellular evidence regarding perioperative changes in cancer cells, their surrounding microenvironment, and host immunity.
Assessed emerging diagnostic modalities and ongoing clinical trials aimed at identifying and targeting minimal residual disease around the time of surgery.
Surgical intervention promotes local microenvironmental alterations and systemic immune suppression that inadvertently facilitate residual tumor cell survival, proliferation, and metastatic spread.
Active clinical investigations are identifying novel diagnostic biomarkers and perioperative therapies to intercept tumor progression during the vulnerable post-resection period.

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Implication

Review highlights how surgical stress accelerates minimal residual cancer progression in solid tumors, indicating the need for targeted perioperative therapy.

Abstract

Although surgery is the main treatment for solid tumors, it could enhance the growth and metastasis of minimal residual cancer. In this review article we have discussed the perioperative changes in cancer cells and surrounding environment as well as the alterations in the immune system. Several trials are ongoing to develop new diagnostic and therapeutic options for minimal residual cancer after surgery.

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Amin et al. (2018) studied this question.

synapsesocial.com/papers/6a1c1d39ea84844e355f76a6 https://doi.org/10.14302/issn.2372-6601.jhor-18-2396

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Perioperative Period is a Critical Gap for Minimal Residual Cancer Cells Progression and Therapy: Biological and Molecular Based Evidences

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Perioperative Period is a Critical Gap for Minimal Residual Cancer Cells Progression and Therapy: Biological and Molecular Based Evidences

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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