Key result
Macrophages and monocytes play a critical role in myocardial damage and cardiac remodeling after myocardial infarction, representing potential therapeutic targets to modulate myocardial healing.
Understanding the distinct origins and functions of cardiac macrophage subsets may provide novel therapeutic targets for modulating inflammation and improving cardiac remodeling after myocardial infarction.
Macrophage modulation merits targeted investigation post-MI; leaves open whether it improves remodeling in prospective trials.
Ischemic heart disease is a common condition and a leading cause of mortality and morbidity. Macrophages, besides their role in host defense and tissue homeostasis, are critical players in the pathophysiological processes induced by myocardial infarction. In this article we will summarize the current understanding of the role of monocytes and macrophages in myocardial damage and cardiac remodeling in relation to their origin and developmental paths. Furthermore, we describe their potential implications in therapeutic strategies to modulate myocardial healing and regeneration.
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Weinberger et al. (2015) conducted a review in Myocardial infarction. Macrophages and monocytes play a critical role in myocardial damage and cardiac remodeling after myocardial infarction, representing potential therapeutic targets to modulate myocardial healing.
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