Do apical aneurysms predict sudden cardiac death in hypertrophic cardiomyopathy?

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Hypertrophic cardiomyopathy (HCM). Intervention: Left ventricular apical aneurysms. Primary outcome: Sudden cardiac death (SCD).

Massimiliano Lorenzini; Perry Elliott

doi:10.1093/eurheartj/ehad122

March 16, 2023European Heart JournalOpen Access

Do apical aneurysms predict sudden cardiac death in hypertrophic cardiomyopathy?

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Key result

Available data do not support the use of left ventricular apical aneurysms as an independent predictor of sudden cardiac death in hypertrophic cardiomyopathy due to selection bias and confounders.

Why the study?

Does the presence of LV apical aneurysms predict sudden cardiac death in patients with hypertrophic cardiomyopathy?

Structured PICO

Does the presence of LV apical aneurysms predict sudden cardiac death in patients with hypertrophic cardiomyopathy?

P

Population

Patients with hypertrophic cardiomyopathy (HCM)

I

Intervention

Presence of left ventricular (LV) apical aneurysms

O

Outcome

Sudden cardiac death (SCD) or equivalent events (e.g., appropriate ICD shocks, resuscitated cardiac arrest)hard clinical

Limitations

Significant selection bias in published retrospective series
Presence of important confounders such as previous VT/VF or reduced LV ejection fraction
Small absolute number of events in the published series precludes analysis of independent predictive value
Small absolute number of events in published series precludes analysis of independent predictive value
Significant selection bias in published studies
Confounding by well-established risk factors like prior VT/VF and reduced LVEF

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Answers are grounded in this paper and cite their sources.

Implication

The authors argue that current evidence is insufficient to support LV apical aneurysms as an independent predictor of sudden cardiac death in HCM, challenging recent AHA/ACC guidelines.

Abstract

Journal Article Do apical aneurysms predict sudden cardiac death in hypertrophic cardiomyopathy? Get access Massimiliano Lorenzini, Massimiliano Lorenzini Barts Heart Centre, St. Bartholomew's Hospital, W Smithfield, London EC1A 7BE, UKUniversity College London, Institute of Cardiovascular Science, 62 Huntley St, London WC1E 6DD, UK Corresponding author. Tel: +44 02074804843, Email: Dr.m.lorenzini@gmail.com https://orcid.org/0000-0002-1831-7853 Search for other works by this author on: Oxford Academic PubMed Google Scholar Perry M Elliott Perry M Elliott Barts Heart Centre, St. Bartholomew's Hospital, W Smithfield, London EC1A 7BE, UKUniversity College London, Institute of Cardiovascular Science, 62 Huntley St, London WC1E 6DD, UK https://orcid.org/0000-0003-3383-3984 Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, Volume 44, Issue 17, 1 May 2023, Pages 1519–1521, https://doi.org/10.1093/eurheartj/ehad122 Published: 16 March 2023 Article history Received: 28 September 2022 Revision received: 21 December 2022 Accepted: 10 January 2023 Published: 16 March 2023

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Cite This Study

Lorenzini et al. (2023) conducted an editorial in Hypertrophic cardiomyopathy (HCM). Left ventricular apical aneurysms was evaluated on Sudden cardiac death (SCD). Available data do not support the use of left ventricular apical aneurysms as an independent predictor of sudden cardiac death in hypertrophic cardiomyopathy due to selection bias and confounders.

synapsesocial.com/papers/6a1c200b0a1f7575939d8d48 https://doi.org/10.1093/eurheartj/ehad122

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Do apical aneurysms predict sudden cardiac death in hypertrophic cardiomyopathy?

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Do apical aneurysms predict sudden cardiac death in hypertrophic cardiomyopathy?

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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