Reversible Renal Failure due to the Use of Captopril in a Renal Allograft Recipient Treated with Cyclosporin

Angiotensin-converting enzyme (ACE) inhibitors are widely used for the treatment of hypertension, but caution is advised because these drugs may induce reversible acute renal failure. Although this has been ascribed in some cases to nephrotoxicity, hypotension, a hypersensitivity reaction, and interstitial nephritis, most cases have been associated with stenosis of the renal arteries or arterioles occurring in either native or transplanted kidneys. We describe a case of reversible acute renal failure due to the use of captopril in a renal allograft recipient who had no evidence of any of these conditions, but who was also receiving cyclosporin therapy.