Key result
Baseline C-reactive protein levels >26.35 mg/dl significantly increased the risk of developing new-onset arrhythmias during the in-hospital phase of acute ST-elevation myocardial infarction (OR 4.0).
Why the study?
Arrhythmias and conduction disturbances are common during AMI and a major cause of pre-hospital death, prompting investigation of common predictors for in-hospital arrhythmias in STEMI patients.
Do elevated CRP, peak CKMB, and inferior infarct localization predict the development of arrhythmias in patients with acute STEMI?
Observational (n=90)
No
Do elevated CRP, peak CKMB, and inferior infarct localization predict the development of arrhythmias in patients with acute STEMI?
Elevated baseline CRP levels, peak CKMB, and inferior infarct localization are significant predictors of new-onset arrhythmias during the in-hospital phase of acute STEMI.
May aid early arrhythmia risk identification in acute STEMI; hypothesis-generating and should not yet change practice.
Purpose: Arrhythmias and conduction disturbances are common during acute myocardial infarction (AMI) and a major cause of death in the pre-hospital phase. The aim of this study was to investigate common predictors for all arrhythmias in patients with ST elevation AMI (STEMI) during in-hospital phase. Materials and Methods: Ninety patients (74 male, 55 ±11 years) with acute STEMI were included. Clinical charesteristics were recorded and laboratory parameters including serum C- reactive protein (CRP), creatinine kinase MB (CKMB) and potassium levels were measured. The patients were divided into two groups according to development of arrhythmias.Results: Group 1 (n=42) patients had new onset arrhythmias and Group 2 (n=48) patients had without arrhythmias. Median baseline CRP levels were significantly higher in group 1 (36.6 (21.8-77) mg/dl vs. 21.8 (24.2-30.7) mg/dl), especially in patients with atrial fibrillation and ventricular arrhythmias. Logistic regression analysis showed that baseline higher CRP level, peak CKMB level and inferior localization of AMI were significantly associated with the development of arrhythmia following AMI. Conclusion: Levels of CRP and CKMB and inferior infarct localization have predictive values for all the arrhythmic events during AMI. CRP levels were found to be associated with both atrial and ventricular arrhythmias. The assessment of CRP levels can be used to detect patients at high risk for arrhythmic events after STEMI.
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Dursun et al. (2019) conducted an observational in Acute ST elevation myocardial infarction (STEMI) (n=90). Elevated C-reactive protein (CRP >26.35 mg/dl) vs. CRP ≤26.35 mg/dl was evaluated on Development of new onset arrhythmias (OR 4.0, 95% CI 1.2-12.9, p=0.018). Baseline C-reactive protein levels >26.35 mg/dl significantly increased the risk of developing new-onset arrhythmias during the in-hospital phase of acute ST-elevation myocardial infarction (OR 4.0).
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