A novel approach to chiral recognition of small molecules using the classical ninhydrin agent is introduced. Well-defined dynamic covalent chemistry with amines and amino alcohols was developed and applied to quantitative ee sensing with good accuracy using a straightforward mixing protocol and subsequent circular dichroism measurements. This chiroptical assay is fast, broadly useful, practical and repurposes an inexpensive reagent known for more than 100 years in a new application.
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Pilicer et al. (2020) studied this question.
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