Key result
Concurrent gastric cancer and incidental PE linked to ~117% higher mortality vs sequential diagnosis.
Why the study?
No study had examined the presentation and prognosis of incidental pulmonary embolism in gastric cancer patients.
Does anticoagulation therapy improve survival in patients with advanced gastric cancer complicated by incidental pulmonary embolism?
Cohort (n=90)
No
Does anticoagulation therapy improve survival in patients with advanced gastric cancer complicated by incidental pulmonary embolism?
Hazard Ratio: 2.174 (95% CI 1.21–4.22)
Absolute Event Rate: 11.8% vs 19.2%
p-value: p=0.022
Active anticoagulant therapy is associated with improved survival in patients with advanced gastric cancer and incidental pulmonary embolism, including those with peripheral emboli.
May warrant closer monitoring in concurrent gastric cancer and IPE; leaves open anticoagulation effects on survival pending prospective data.
OBJECTIVE: Cancer is well known as the most important risk factor for the emergence of pulmonary embolism (PE). The incidence of incidental PE (IPE) has increased with widely use of multi-detector-row computed tomography (CT) technology. Simultaneously, more new cancer patients diagnosed concomitantly with IPE are found. No study has examined the presentation and prognosis of incidental pulmonary embolism (IPE) in gastric cancer patients. The aim of this study was to analyse prognostic factors in patients with advanced gastric cancer complicated with IPE. PATIENTS AND METHODS: -test if non-normally distributed. The Chi-squared test (or Fisher's exact test where appropriate) was used to compare categorical variables. The Kaplan-Meier method and the Log rank test were used for survival analysis. Independent prognostic factors for survival were determined using a Cox proportional hazards model. A two-sided P-value < 0.05 was considered statistically significant. RESULTS: Nineteen patients were diagnosed with IPE concomitantly with gastric cancer. Concurrence of gastric cancer and IPE, lack of anticoagulation therapy, and location of IPE were associated with survival. After adjusting for age and sex, the concurrence of gastric cancer and IPE, lack of anticoagulation, and central IPE independently influenced the survival of advanced gastric cancer patients with IPE. Subgroup analysis of patients with peripheral pulmonary embolisms confirmed that anticoagulant therapy provided a survival benefit. CONCLUSION: Concurrence of gastric cancer and IPE may be a prognostic factor for advanced gastric cancer patients with IPE.
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Qiu et al. (2021) conducted a cohort in Advanced gastric cancer with incidental pulmonary embolism (n=90). Concurrence of gastric cancer and incidental pulmonary embolism vs. Sequential diagnosis of incidental pulmonary embolism was evaluated on Overall survival (median months) (HR 2.174, 95% CI 1.21-4.22, p=0.022). Concurrence of gastric cancer and incidental pulmonary embolism was associated with significantly shorter overall survival compared to sequential diagnosis (HR 2.174).
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