Key result
The estimation of cardiac potential energy during work-loop contractions is ambiguous and subjective, rendering it an unreliable metric for inferring cardiac efficiency.
The estimation of cardiac potential energy is ambiguous during work-loop contractions, challenging the physiological basis of Suga's isoefficiency concept.
In this Viewpoint, we reflect on our collective studies and our understanding of Suga’s pressure-volume area (PVA) concept (8, 11, 12) to illustrate both the conceptual vagueness and the methodological uncertainty in the estimation of PE. This Viewpoint is an appeal to researchers in this field to discontinue using the potential energy concept to infer cardiac efficiency. Hereinafter, we label PE as U to signify that its estimation is often uncertain.
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Han et al. (2024) conducted an editorial in Cardiac energetics. The estimation of cardiac potential energy during work-loop contractions is ambiguous and subjective, rendering it an unreliable metric for inferring cardiac efficiency.
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