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In early lesions of experimental allergic encephalomyelitis in rats Thorotrast passes through vessel walls concomitant with invading mononuclear cells. The particles are found between the endothelial cells, within the vacuolated basement membrane, and in the extracellular space between glial processes. In advanced lesions, markedly widened extracellular spaces often contain threads of fibrin along with Thorotrast. Demyelination occurs in the presence of mononuclear cells which invade the myelin sheath, peeling off individual myelin lamellae or the entire sheath. A separate alteration of myelin consists of a regular widening of the interlamellar space beginning with the outer layers. The possibility that this change precedes the cellular invasion of the myelin sheath is discussed. (Author)
Lampert et al. (Fri,) studied this question.