Elevated serum NEAT1 and reduced miR-425-3p were independent risk factors for poor 12-month prognosis in children with viral myocarditis, with elevated NEAT1 showing an OR of 9.714.
Observational (n=210)
No
Do serum levels of NEAT1 and miR-425-3p have diagnostic and prognostic value in children with viral myocarditis?
Serum NEAT1 and miR-425-3p levels are significantly altered in children with viral myocarditis and serve as independent diagnostic and prognostic biomarkers.
Estimación del efecto: OR 9.714 (95% CI 3.204-29.453)
valor p: p=<0.05
BACKGROUND: Viral myocarditis (VMC) is common in children. Previous studies have reported the clinical value of nuclear paraspeckle assembly transcript 1 (NEAT1) and microRNA-425-3p (miR-425-3p) in certain diseases, but not in VMC. This article was designed to investigate the expression of long noncoding RNA (lncRNA) NEAT1 and miR-425-3p in the serum of patients with VMC and their clinical significance. METHODS: We assessed VMC and healthy patients and analyzed differences in the expression levels of NEAT1 and miR-425-3p. The correlation and targeting relationship between the two were reported by Spearman correlation analysis and luciferase reporter assay. ROC curves were plotted to reflect the diagnostic effect of both. In addition, according to the 12-month prognostic effect grouping, patients with VMC were separated into a group with good vs. poor prognosis, and the difference in the expression levels of NEAT1 and miR-425-3p between the two groups were analyzed. The ability of the two markers in the prognosis of VMC was further analyzed by multiple logistic regression. RESULTS: NEAT1 expression was up-regulated in VMC and miR-425-3p expression was down-regulated, and there was a negative correlation and targeting link between the two. The diagnostic efficacy of both NEAT1 and miR-425-3p was higher than that of a single indicator. High expression of NEAT1 and low expression of miR-425-3p were found in VMC patients with poor prognosis. Both were independent influencers of VMC prognosis. CONCLUSION: NEAT1 and miR-425-3p expressions were affected by VMC and had important clinical implications for VMC, indicating for the first time the clinical function of NEAT1 and miR-425-3p in VMC.
Gao et al. (Mon,) conducted a observational in Viral myocarditis (n=210). NEAT1 and miR-425-3p vs. Healthy controls and good prognosis group was evaluated on Poor prognosis at 12 months (elevated NEAT1) (OR 9.714, 95% CI 3.204-29.453, p=<0.05). Elevated serum NEAT1 and reduced miR-425-3p were independent risk factors for poor 12-month prognosis in children with viral myocarditis, with elevated NEAT1 showing an OR of 9.714.