Biopsy vs comprehensive embryo/blastocyst analysis: a closer look at embryonic chromosome evaluation

January 1, 2025Human Reproduction OpenOpen Access

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The study aims to compare chromosomal evaluation of whole embryos to biopsied samples in human pre-implantation embryos. It investigates the differences in euploidy and mosaicism rates.
Assessed 221 whole human embryos/blastocysts using next-generation sequencing from 2019 to 2022.
Mosaicism was diagnosed using a threshold of 30-70%, classifying 30-70% aneuploid cells as mosaic.
Analyzed cytogenetic constitution across high-quality, low-quality, and arrested embryos.
Among high-quality blastocysts, the euploidy rate was 82.9% with a mosaic aneuploidy rate of 2.5%.
Euploidy rates for low-quality blastocysts and arrested embryos were 38.6% and 13.0%, respectively.
Mosaic aneuploidy decreased from 93.2% at the cleavage stage to 40% at the blastocyst stage.

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Compares embryonic chromosome evaluation in whole embryos versus biopsied samples, indicating improved euploidy rates.

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Xu et al. (2025) studied this question.

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