Key result
Earlier age at menarche significantly predicted non-contact ACL injury in female collegiate athletes, with an odds ratio of 0.36 for each year increase in age at menarche.
Why the study?
How variation in pubertal development affects non-contact ACL injury risk within female athletes is poorly understood.
Does earlier age at menarche increase the risk of ACL injury and anterior knee laxity in female collegiate athletes?
Case-Control (n=134)
No
Does earlier age at menarche increase the risk of ACL injury and anterior knee laxity in female collegiate athletes?
Earlier age at menarche is associated with a higher risk of non-contact ACL injury in female collegiate athletes, potentially related to cumulative estrogen exposure affecting knee laxity.
Earlier menarche may inform ACL risk stratification in female athletes; hypothesis-generating and needs prospective validation before practice change.
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Froehle et al. (2020) conducted a case-control in Anterior Cruciate Ligament (ACL) Injury (n=134). Earlier age at menarche vs. Later age at menarche was evaluated on Non-contact ACL injury status (OR 0.36, 95% CI 0.17-0.75, p=<0.01). Earlier age at menarche significantly predicted non-contact ACL injury in female collegiate athletes, with an odds ratio of 0.36 for each year increase in age at menarche.
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