Aging and mechanobiological cues interact to drive progressive structural, functional, and molecular remodeling in the pulmonary vasculature, contributing to age-related pulmonary diseases.
Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.
Dieffenbach et al. (Mon,) conducted a review in Aging-associated pulmonary vascular remodeling. Aging and mechanobiological cues interact to drive progressive structural, functional, and molecular remodeling in the pulmonary vasculature, contributing to age-related pulmonary diseases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: