Key result
Aging and mechanobiological cues interact to drive progressive structural, functional, and molecular remodeling in the pulmonary vasculature, contributing to age-related pulmonary diseases.
Why the study?
Growing evidence supports the role of endothelial dysfunction and vascular remodeling in age-related declining lung function, but the underlying mechanisms remain elusive.
Aging and mechanobiological cues interact to drive progressive vascular remodeling, stiffening, and endothelial dysfunction in the pulmonary circulation, contributing to pulmonary disease pathogenesis.
Mechanobiological pathways merit exploration in elderly pulmonary vascular disease; leaves open clinical validation.
Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.
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Dieffenbach et al. (2021) conducted a review in Aging-associated pulmonary vascular remodeling. Aging and mechanobiological cues interact to drive progressive structural, functional, and molecular remodeling in the pulmonary vasculature, contributing to age-related pulmonary diseases.
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