Key result
NR3C1 gene polymorphisms show no association with carotid artery stenosis in CAD.
Why the study?
Atherosclerosis development may be associated with glucocorticoids, but the association between NR3C1 gene polymorphisms and carotid artery stenosis remained to be investigated.
Do Tth111I, N363S, and ER22/23EK-NR3C1 polymorphisms associate with the incidence or severity of carotid artery stenosis?
Case-Control (n=205)
Do Tth111I, N363S, and ER22/23EK-NR3C1 polymorphisms associate with the incidence or severity of carotid artery stenosis?
Common NR3C1 gene variants (Tth111I, N363S, ER22/23EK) do not appear to influence the incidence or severity of carotid artery stenosis in a Polish population.
No support for NR3C1 genotyping in carotid stenosis risk assessment; leaves open roles for other variants or populations.
Background: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Early diagnosis and elimination of risk factors are crucial for better managing CVDs. Atherosclerosis, whose development might be associated with glucocorticoids (GCs), is a critical factor in the development of carotid artery (CA) stenosis and most other CVDs. Aim: To investigate the association of Tth111I, N363S, and ER22/23EK-NR3C1 polymorphisms and the incidence of CA stenosis. Methods: The study group consisted of 117 patients diagnosed with coronary artery disease (CAD) and CA stenosis and 88 patients with CAD and ruled out CA stenosis. Genomic DNA was extracted from blood, and genotyping was carried out using Tth111I, N363S, and ER22/23EK-NR3C1 polymorphism sequencing. Results: No significant association between studied polymorphisms and the incidence or the severity of CA stenosis in the Polish population with CAD was found. Conclusion: This is the first study that proves that common NR3C1 gene variants do not influence CA stenosis and probably are not associated with atherosclerosis. The search for genes that can act as prognostic markers in predicting CA stenosis is still ongoing.
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Gorący et al. (2022) conducted a case-control in Coronary artery disease and carotid artery stenosis (n=205). NR3C1 gene polymorphisms (Tth111I, N363S, ER22/23EK) vs. Wild-type genotypes was evaluated on Incidence of carotid artery stenosis. The Tth111I, N363S, and ER22/23EK polymorphisms of the NR3C1 gene showed no significant association with the incidence or severity of carotid artery stenosis in Polish patients with coronary artery disease.
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