Key result
An optimised single-point marker (SPM-O) of the basal right ventricular freewall predicted right ventricular ejection fraction more accurately than other 2D markers (median error 2.8 ml vs 3.6 ml).
Why the study?
Does an optimized single-point marker (SPM-O) improve prediction of right ventricular ejection fraction compared to conventional 2D markers in healthy volunteers?
Cross-Sectional (n=640)
No
Does an optimized single-point marker (SPM-O) improve prediction of right ventricular ejection fraction compared to conventional 2D markers in healthy volunteers?
Systolic motion of the basal RV freewall (SPM-O) predicts global RV function more accurately than conventional 2D estimators like TAPSE, though 3D contractile patterns limit the accuracy of all 2D markers.
Summary Right ventricular (RV) function has prognostic value in acute, chronic and peri‐operative disease, although the complex RV contractile pattern makes rapid assessment difficult. Several two‐dimensional (2D) regional measures estimate RV function, however the optimal measure is not known. High‐resolution three‐dimensional (3D) cardiac magnetic resonance cine imaging was acquired in 300 healthy volunteers and a computational model of RV motion created. Points where regional function was significantly associated with global function were identified and a 2D, optimised single‐point marker (SPM‐O) of global function developed. This marker was prospectively compared with tricuspid annular plane systolic excursion (TAPSE), septum‐freewall displacement (SFD) and their fractional change (TAPSE‐F, SFD‐F) in a test cohort of 300 patients in the prediction of RV ejection fraction. RV ejection fraction was significantly associated with systolic function in a contiguous 7.3 cm 2 patch of the basal RV freewall combining transverse (38%), longitudinal (35%) and circumferential (27%) contraction and coinciding with the four‐chamber view. In the test cohort, all single‐point surrogates correlated with RV ejection fraction (p < 0.010), but correlation (R) was higher for SPM‐O (R = 0.44, p < 0.001) than TAPSE (R = 0.24, p < 0.001) and SFD (R = 0.22, p < 0.001), and non‐significantly higher than TAPSE‐F (R = 0.40, p < 0.001) and SFD‐F (R = 0.43, p < 0.001). SPM‐O explained more of the observed variance in RV ejection fraction (19%) and predicted it more accurately than any other 2D marker (median error 2.8 ml vs 3.6 ml, p < 0.001). We conclude that systolic motion of the basal RV freewall predicts global function more accurately than other 2D estimators. However, no markers summarise 3D contractile patterns, limiting their predictive accuracy.
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Dawes et al. (2018) conducted a cross-sectional in Healthy volunteers (n=640). Optimised single-point marker (SPM-O) vs. TAPSE and other 2D markers was evaluated on Median absolute error in prediction of right ventricular ejection fraction (p=<0.001). An optimised single-point marker (SPM-O) of the basal right ventricular freewall predicted right ventricular ejection fraction more accurately than other 2D markers (median error 2.8 ml vs 3.6 ml).
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