Background: Regulation between GPCRs and -arrestins in endosomes has never been reported. Results: A novel ERK regulatory site in -arrestin-2 controls the binding to GPCRs in endosomes, and receptor trafficking and signaling. Conclusion: Differential MAPK-dependent regulation of endosomal complexes exists among -arrestin subtypes and species. Significance: Such divergent mode of regulation may help understanding the physiological role of the endosomal GPCR/ -arrestins signaling axis.
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Khoury et al. (2014) studied this question.
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