Key result
Valve surgery for left-sided infective endocarditis was not associated with a 6-month survival benefit compared to nonsurgical management (adjusted HR 1.3; 95% CI 0.5-3.1 in matched cohort).
Why the study?
Does valve surgery reduce all-cause 6-month mortality in patients with left-sided infective endocarditis?
Observational (n=546)
Does valve surgery reduce all-cause 6-month mortality in patients with left-sided infective endocarditis?
Effect estimate: adjusted HR 1.3 (95% CI 0.5-3.1)
Absolute Event Rate: 27.1% vs 23.7%
Valve surgery for left-sided infective endocarditis was not associated with a 6-month survival benefit in this propensity-matched cohort, highlighting the need for prospective randomized trials.
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No survival benefit seen with surgery in matched cohort; leaves open optimal IE management pending randomized trials.
Tleyjeh et al. (2007) conducted an observational in left-sided infective endocarditis (n=546). Valve surgery vs. Nonsurgical management was evaluated on All-cause 6-month mortality (adjusted HR 1.3, 95% CI 0.5-3.1). Valve surgery for left-sided infective endocarditis was not associated with a 6-month survival benefit compared to nonsurgical management (adjusted HR 1.3; 95% CI 0.5-3.1 in matched cohort).
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